FAME results at the Nutrition Society Summer Conference 2021
FAME results at EDEG 2021: Novel biomarkers of dairy are related to diabetes risk
Marcela Prada, a PhD student at the consortium partner DIfE, presented the results of her work at the annual meeting of the European Diabetes Epidemiology Group (EDEG). Novel lipidomics profiling in the EPIC-Potsdam study allowed an in-depth analysis of odd-chain fatty acid-containing lipids across a range of different lipid classes and their association with the new onset of type 2 diabetes in this prospective cohort.
FAME outcomes presented at the ERA-HDHL "Biomarkers for Nutrition and Health" Final Seminar
Matthias Schulze, as project coordinator, presented the progress and results of the FAME consortium at the Final Seminar of the Call for Joint Transnational Research Proposals: “Biomarkers for Nutrition and Health”, co-founded by ERA-HDHL. The presentation highlighted results of the work carried out across the 3 different work packages by project partners, e.g. on lipidomics and cardiometabolic diseases, novel biomarkers of dairy food consumption, and genetic and non-genetic determinants of PUFA status.
Our consortium partners were also present, together with other experts, including Scientific Advisory and Stakeholders Board members of the JPI HDHL and a representative of the European Commission.
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Dietary fat modulation of lipidomic biomarkers for cardiovascular disease and type 2 diabetes
The consortium partners from DIfE and the University of Reading investigated the molecular relationships of diet, lipid biomarkers and the development of metabolic diseases. The researchers used lipidomics, a modern analytical method, to identify those lipids that are statistically associated with cardiovascular diseases and type 2 diabetes. In addition, the scientists found that a diet with an increased proportion of unsaturated fatty acids leads to a reduction in risk-associated lipids and an increase in low-risk lipids.
The results and complete article can be found here: “Deep Lipidomics in Human Plasma: Cardiometabolic Disease Risk and Effect of Dietary Fat Modulation".
Dr. Fabian Eichelmann discusses the article in a podcast available here: https://circulation.libsyn.com/circulation-july-5-2022-issue
Consumption of dairy food and cardiovascular disease risk
Laury Sellem, a doctoral researcher at the consortium partner UoR, and colleagues from the University Paris Sorbonne Nord in France investigated the associations between the consumption of dairy foods and the risk of cardiovascular disease risk in the French prospective cohort study NutriNet-Santé. They found that despite dairy foods being important sources of dietary saturated fat, their consumption was not associated with overall cardiovascular disease or coronary heart disease risks. However, they observed that high consumption of fermented dairy (e.g. cheese and yogurt) was associated with a decreased risk of cerebrovascular disease (e.g. stroke and transient ischaemic attacks). These results suggest a potential differential effect of specific dairy foods on cardiovascular health.
Read the full article at the following link: "Consumption of dairy products and CVD risk: results from the French prospective cohort NutriNet-Santé".
Lipidomics signatures related to heart failure risk
Leveraging the comprehensive lipidomics data in two large human studies, the PREDIMED-trial in Spain and the EPIC-Potsdam cohort in Germany, Wittenbecher, and colleagues from the FAME consortium conducted the first comprehensive prospective lipidomics study on heart failure risk. Single lipids and lipid patterns, particularly ceramides and phosphatidylcholines with palmitate (C16:0), were associated with the risk of developing heart failure in the PREDIMED trial. The prospective associations of several lipids and lipid patterns with heart failure risk were externally validated in the EPIC-Potsdam cohort. These results suggest that plasma lipidomics profiling reflects perturbations in lipid metabolism preceding heart failure onset and generates putative biomarkers of heart failure risk.
Find the full article in the following link "Lipid Profiles and Heart Failure Risk: Results From Two Prospective Studies".
Click here to find out about other publications from FAME project partners.