The overall objective of the integrated work programme is to use existing biobanked samples and dietary and phenotype data from cohort studies and randomized controlled dietary intervention trials to:
- identify novel FA and lipidomics biomarkers of cardiometabolic health which could replace or complement ‘established’ FA profiles as more sensitive biomarkers of status and of future cardiometabolic disease events,
- establish relationships between whole diets and specific foods with tissue status of FA as explanatory factors for how diet relates to cardiometabolic health and
- investigate genetic determinants of FA status and metabolism which may modify the effects of dietary intake.
H1: FA metabolites are novel biomarkers of cardiometabolic health.
H2: Odd-numbered SFA and trans-FA, are a valid biomarker of dairy fat intake and confer a benefit on intermediate health markers and reduction in cardiometabolic related conditions.
H3: FA status may be modulated in an intake independent fashion, e.g. by the intake of plant-derived bioactives from whole diets.
H4: Genetic variants in PUFA elongation, desaturation and oxygenation genes modify dietary effects on PUFA status and health outcomes.