PUFA metabolism, genetics, and type 2 diabetes risk
FAME scientists at DIfE previously investigated the role of fatty acids in type 2 diabetes incidence using biomarkers and genetic analyses in the EPIC-Potsdam Study and observed a strong association of membrane concentrations of gamma-linolenic acid/dihomo-gamma-linolenic acid with risk. That PUFA metabolism might be relevant for the risk of type 2 diabetes was furthermore supported by a genetic approach to detect genetic determinants of diabetes-associated lipid metabolites (Jäger et al. Sci Rep. 2017). Using targeted metabolomics, we confirmed the importance of desaturases (FADS1). We also identified a novel metabolite locus (MOGAT2) in single variant analyses.