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PUFA metabolism, genetics, and type 2 diabetes risk

FAME scientists at DIfE previously investigated the role of fatty acids in type 2 diabetes incidence using biomarkers and genetic analyses in the EPIC-Potsdam Study and observed a strong association of membrane concentrations of gamma-linolenic acid/dihomo-gamma-linolenic acid with risk. That PUFA metabolism might be relevant for the risk of type 2 diabetes was furthermore supported by a genetic approach to detect genetic determinants of diabetes-associated lipid metabolites (Jäger et al. Sci Rep. 2017). Using targeted metabolomics, we confirmed the importance of desaturases (FADS1). We also identified a novel metabolite locus (MOGAT2) in single variant analyses.

The figure shows the network structure of metabolites within EPIC-Potsdam and related genetic variants (Source: Jäger et al. Sci Rep. 2017; 7: 6037; this article is licensed under a Creative Commons Attribution 4.0 International License).
The figure shows the network structure of metabolites within EPIC-Potsdam and related genetic variants (Source: Jäger et al. Sci Rep. 2017; 7: 6037; this article is licensed under a Creative Commons Attribution 4.0 International License)